Turkey is an ideal choice for many Middle East and European patients who seek a high quality of health services and still at affordable prices. Implant Akademi International Dental Clinic serves patients not only from Turkey but also from other countries..

The problem of missing teeth in dentistry is nowadays overcome with the application of dental implants. Despite a high rate of successfully integrated dental implants, there is a lot of data on implant failure due to inflammatory processes in the implant surrounding hard and soft tissues, such as peri-implantitis. Peri-implantitis  represents a destructive inflammatory process, in soft tissues and bone loss around an osseointegrated dental implant in function. Besides the well-known role of etiologic factors such as bacterial infections and biomechanical factors, recent studies indicate the genetic basis of peri-implantitis susceptibility. Risk indicators associated with periodontal disease, poor oral habits, and smoking habits greatly contribute to the development of peri-implantitis. Even when exposed to similar risk factors,
not all patients will develope peri-implantitis, which highlights the importance of genetic predisposition and differences between populations. Thus, elucidating the genetic basis and identification of molecular biomarkers could be used for prediction of peri-implantitis occurrence and improved treatment and follow-up procedures in patients with dental implants. If one or more gene polymorphisms could affect the status of peri-implant tissues, genetic testing could contribute to informing patients about the potential risks. It can be assumed that candidate genes for peri-implantitis susceptibility may include cluster of differentiation 14 (CD14) and cytokines, such as interleukin (IL)6, IL10, interleukin 1 receptor antagonist (IL1ra), and tumor necrosis factor alpha (TNFα) as immunoregulatory molecules. Cytokines are proteins secreted by the cells of innate and adaptive immunity that mediate and modulate many cellular functions of the immune response to infection. CD14 plays an important role in immune defense against bacterial infection in peri-implantitis. Dental clinics in Turkey are ready to overcome the implant failure and other bone loss problems with the reliable and exact implant treatments to the toothless patients by the highly experienced dental surgeons. The etiology and pathogenesis of peri-implantitis are not clearly known, which indicates a need to identify the molecular markers for peri-implantitis susceptibility. In the current literature, there are a limited number of association studies between gene polymorphisms and peri-implantitis occurrence. Individual variation in local cytokine production could occur as a result of genetic, epigenetic, or environmental heterogeneity. In the present study, CD14-159 genotypes containing at least one polymorphic allele were associated with a decreased peri-implantitis risk, which corresponds to recently published results indicating possible protective effects in Tallele carriers. The observed results could be explained with functionality of the polymorphism, since it is known that CD14-159 polymorphism affects the gene expression level, possibly due to position in the promoter region close to the Sp1 transcription factor binding site. The presence of the T allele in the promoter region of the CD14 gene, and the TT genotype, results in an increased level of the serumsoluble form of CD14 receptor (sCD14). CD14-159 polymorphism was analyzed in several studies regarding periodontitis, implying the importance of CD14 polymorphism for periodontitis susceptibility inferred from a conducted meta-analysis.

Please do not hesitate to reach us for further information.

Call or Whatsapp: 0533 658 58 93

www.dentistturkey.com

info@dentalclinicsturkey.com